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Philippe's project

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Project description

Mosquito testing

Force and displacement measurements are central to the understanding of various physical, biological, and medical systems. Different approaches exist with varying sensitivity. SENSORICA is proposing a new technology based on optical properties of optical fibers consisting mainly of increase light loss with fiber bending. This technology could be useful to study dynamic mechanical properties of biological systems, from organs to sub-cellular structures. Proof-of-concept has been done but formal characterization and validation in a biological environment and at the cellular level is still needed to validate the potential of this innovative approach.

The proposed research partnership is central to the development of the technology. Here, we propose a series of tests that can be labeled as 1) System characterization and validation and 2) experimental tests at the cardiac cellular and heart tissue level.
  1. System characterization (aim to characterize three fiber diameters):
    1. Develop a procedure and related hardware/software to characterize the optical fiber mechanical properties..
    2. Evaluate the lifetime of the optical fiber sensor by calculating the change in rigidity following a fatigue testing by cyclic movement.
    3. Determine the frequency response of the system and sensitivity as a function of fiber diameter. Evaluate the possibility of adding a stage of voltage-offset to the electronic
    4. circuit to use the maximum dynamic range of the analog to digital converter.
    5. Explore different optical setups to increase sensitivity (ex. The multi-pass sensor, by adding a semi-transparent mirror inline)
  2. Experimental tests and validation for cardiac applications. Testing of frequency-dependent decrease in force. Evaluate set of fiber diameters for measurement of:
    1. Cellular level force.
      1. Cultured neonatal cardiomyocytes
      2. Freshly isolated adult cardiomyocytes
    2. Organ level force.
    3. Isolated perfused heart

Important docs


This is a collaborative project to respond to the current needs of Canadian space Agency. Open submission doc

Database: some content is in SENSORICA/Mosquito/Project-Philippe Comtois/CSA folder, other in Tactus/grant_CSA Dropbox.  

Medical project

Design a catheter with force sensing and muscle cell stimulation capability.  


[This list will be replaced with a UI/script which will automatically pull info from the activity log, and display members
involved and their relative contribution. See infrastructure activity cluster for more on infrastructure development.]

Main Database

Main Database for this project: SENSORICA/Projects/Philippe Comtoi 
Use mosquito_phil_project tag for Diigo


  • The Mosquito measures muscle contraction During the night between Jan 28 and 29 Ivan, Tibi and Daniel obtained the first biological results with the Mosquito Scientific Instrument at Phil's lab. They used the Mosquito ...
    Posted Feb 13, 2013, 6:44 PM by Tiberius Brastaviceanu
  • Activation and Relaxation of skinned muscles Fresh results obtained by Ivan and James at Phil's lab. You can see activation and relaxation of a small bundle of skinned muscle cells (their membrane have been digested ...
    Posted Jan 29, 2013, 11:29 AM by Tiberius Brastaviceanu
  • Electrical stimulation of sample, we're building understanding This week we made some progress at Phil's lab. I remind you that the end goal is to characterize the Mosquito and to obtain some meaningful results on animal ...
    Posted Dec 21, 2012, 2:07 PM by Tiberius Brastaviceanu
  • Second trial of the Mosquito on a real sample After our last group meeting on Tuesday 27 Nov, 2012 (meeting notes - members only) we accelerated the pace of Philippe's project. The deadline is fast-approaching and we need ...
    Posted Nov 29, 2012, 11:52 AM by Tiberius Brastaviceanu
  • Installation of Mosquito and first tests November 14, 2012, we installed the Mosquito on the microscope and performed the first tests. The picture bellow shows the system without the xyz piezo, which will probably be ready ...
    Posted Nov 14, 2012, 7:02 PM by Tiberius Brastaviceanu
Showing posts 1 - 5 of 13. View more »
See more announcements

Contraction and relaxation of skinned muscle

Installation of the Mosquito

Evolution of the project

Work Party, April 01, 2012 

Work Party, Feb 28, 2012